Concepedia

P53-mediated Arrest

p53-Mediated Arrest is a molecular mechanism of cell-cycle arrest characterized by the activation of the tumor suppressor protein p53 in response to cellular stress, which subsequently induces the transcription of downstream target genes that enforce cell-cycle checkpoint control and prevent progression through the cell cycle.

621

Publications

59.2K

Citations

3.2K

Authors

856

Institutions

Publications per year

2017–2026

68

Parents

Publications

621

Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage

Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations

, , +17

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

Wafik S. El‐Deiry, Harper JW, O'Connor Pm et al. · PubMed · 1994 · 2K citations

, , +17

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson et al. · Cell · 1994 · 1.5K citations

, , +17

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

Todd Waldman, K. W. Kinzler, Bert Vogelstein · PubMed · 1995 · 1.2K citations

, , +17

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Aldo Di Leonardo, Steven P. Linke, Kristie Clarkin et al. · Genes & Development · 1994 · 1.2K citations · Full text

, , +17

1–5 of 621

Authors

3.2K

  1. MO
    Moshe Oren

    Weizmann Institute of Science, Israel

    9 publications · 918 citations

    9

    h-index

  2. BV
    Bert Vogelstein

    Johns Hopkins University, United States

    7 publications · 5K citations

    7

    h-index

  3. GR
    George R. Stark

    Cleveland Clinic, United States

    7 publications · 1.4K citations

    7

    h-index

  4. WS
    Wafik S. El‐Deiry

    University of Pennsylvania, United States

    7 publications · 2.7K citations

    7

    h-index

  5. ML
    Munna L. Agarwal

    Case Western Reserve University, United States

    7 publications · 549 citations

    6

    h-index

1–5 of 3.2K

Institutions

856

  1. National Cancer Institute

    Bethesda, United States

    18 h-index

    54 publications

    13K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    45 publications

    9.4K citations

  3. Harvard University

    Cambridge, United States

    16 h-index

    58 publications

    7.5K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    13 h-index

    43 publications

    4.1K citations

  5. Johns Hopkins University

    Baltimore, United States

    13 h-index

    69 publications

    53.8K citations

  6. University of Pennsylvania

    Philadelphia, United States

    12 h-index

    25 publications

    2.6K citations

  7. University of California San Diego

    San Diego, United States

    11 h-index

    37 publications

    6.9K citations

  8. Johns Hopkins Medicine

    Baltimore, United States

    10 h-index

    46 publications

    34.8K citations

1–8 of 856

Venues

  1. Journal of Biological Chemistry

    JBC · 53 publications · 5.8K citations

    44

    h-index

  2. Molecular and Cellular Biology

    MCB · 44 publications · 6.2K citations

    37

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 36 publications · 6.4K citations

    34

    h-index

  4. PubMed

    Repository · 52 publications · 7.8K citations

    33

    h-index

  5. Oncogene

    40 publications · 3.7K citations

    32

    h-index

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