A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs

CC‐1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies

Dale L. Boger, Douglas S. Johnson · Angewandte Chemie International Edition in English · 1996 · 319 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +12

Shape-Dependent Catalysis:  Insights into the Source of Catalysis for the CC-1065 and Duocarmycin DNA Alkylation Reaction

Dale L. Boger, R. M. Garbaccio · Accounts of Chemical Research · 1999 · 143 citations

Pharmacy, Biochemistry, Chemistry +10

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Azidosphingosine Glycosylation in Glycosphingolipid Synthesis

Peter Zimmermann, René Sommer, Thomas Bär et al. · Journal of Carbohydrate Chemistry · 1988 · 129 citations

Life Sciences, Biochemistry, Chemistry +13

An alternative and convenient strategy for generation of substantial quantities of singly 5′-32p-end-labeled double-stranded DNA for binding studies: Development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties

Dale L. Boger, Stephen A. Munk, Hamideh Zarrinmayeh et al. · Tetrahedron · 1991 · 104 citations

Pharmacy, Chemical Biology, Molecular Biology +5