Stephen A. Munk

Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit

Dale L. Boger, Takayoshi Ishizaki, Ronald J. Wysocki et al. · Journal of the American Chemical Society · 1989 · 162 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

Medicine, Medicinal Chemistry, Pharmacology +7

An alternative and convenient strategy for generation of substantial quantities of singly 5′-32p-end-labeled double-stranded DNA for binding studies: Development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties

Dale L. Boger, Stephen A. Munk, Hamideh Zarrinmayeh et al. · Tetrahedron · 1991 · 104 citations

Pharmacy, Chemical Biology, Molecular Biology +5

Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunits

Dale L. Boger, Robert S. Coleman, Benedict J. Invergo et al. · Journal of the American Chemical Society · 1990 · 78 citations

Life Sciences, Biochemistry, Chemistry +6

(+)-CC-1065 DNA alkylation: key studies demonstrating a noncovalent binding selectivity contribution to the alkylation selectivity

Dale L. Boger, Stephen A. Munk, Hamideh Zarrinmayeh · Journal of the American Chemical Society · 1991 · 59 citations

Pharmacy, Chemistry, Molecular Recognition +12