Takayoshi Ishizaki

Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit

Dale L. Boger, Takayoshi Ishizaki, Ronald J. Wysocki et al. · Journal of the American Chemical Society · 1989 · 162 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore

Dale L. Boger, Takayoshi Ishizaki, Hamideh Zarrinmayeh et al. · Journal of the American Chemical Society · 1990 · 136 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit

Dale L. Boger, Takayoshi Ishizaki, Paul A. Kitos et al. · The Journal of Organic Chemistry · 1990 · 115 citations

Natural Sciences, Biochemistry, Chemistry +6

An alternative and convenient strategy for generation of substantial quantities of singly 5′-32p-end-labeled double-stranded DNA for binding studies: Development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties

Dale L. Boger, Stephen A. Munk, Hamideh Zarrinmayeh et al. · Tetrahedron · 1991 · 104 citations

Pharmacy, Chemical Biology, Molecular Biology +5

Synthesis and Antibacterial Activity of 1-(2-Fluorovinyl)-7-substituted-4-quinolone-3-carboxylic Acid Derivatives, Conformationally Restricted Analogues of Fleroxacin

Y. Asahina, Kazuhiko Iwase, Fujio Iinuma et al. · Journal of Medicinal Chemistry · 2005 · 103 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12