Kazuhiko Iwase

Synthesis and Antibacterial Activity of 1-(2-Fluorovinyl)-7-substituted-4-quinolone-3-carboxylic Acid Derivatives, Conformationally Restricted Analogues of Fleroxacin

Y. Asahina, Kazuhiko Iwase, Fujio Iinuma et al. · Journal of Medicinal Chemistry · 2005 · 103 citations · Full text

Synthesis and Antibacterial Activity of the 4-Quinolone-3-carboxylic Acid Derivatives Having a Trifluoromethyl Group as a Novel N-1 Substituent

Y. Asahina, Ichiro Araya, Kazuhiko Iwase et al. · Journal of Medicinal Chemistry · 2005 · 68 citations

Bioorganic Chemistry, Antibacterial Activity, Organic Chemistry +17

Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure–activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity

Koji Ochiai, Satoshi Takita, Tomohiko Eiraku et al. · Bioorganic & Medicinal Chemistry · 2012 · 48 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +9

Estimation of hydrophobicity based on the solvent-accessible surface area of molecules.

Kazuhiko Iwase, Katsuichiro Komatsu, Shuichi Hirono et al. · Chemical and Pharmaceutical Bulletin · 1985 · 43 citations · Full text

Engineering, Log P, Hydrophobic Constant +17

Phosphodiesterase inhibitors. Part 1: Synthesis and structure–activity relationships of pyrazolopyridine–pyridazinone PDE inhibitors developed from ibudilast

Robert W. Allcock, H. Blakli, Zhong‐Tao Jiang et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 42 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +13