Concepedia

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

Lucia Di Marcotullio, Azzura Greco, Daniela Mazzà, Gianluca Canettieri, Laura Pietrosanti, Paola Infante, Sonia Coni, Marta Moretti, Enrico De Smaele, Elisabetta Ferretti,

Oncogene · 2010 · 115 citations · 40 references

DOI

Concepts

References

40

Altered Neural Cell Fates and Medulloblastoma in Mouse <i>patched</i> Mutants

Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins et al. · Science · 1997 · 1.7K citations

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The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Lufen Chang, Hideaki Kamata, Giovanni Solinas et al. · Cell · 2006 · 699 citations · Full text

, , +14

Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

Pei‐Jung Lu, Xiao Zhen Zhou, Minhui Shen et al. · Science · 1999 · 686 citations

, , +17

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

Shigetsugu Hatakeyama, Masayoshi Yada, Masaki Matsumoto et al. · Journal of Biological Chemistry · 2001 · 585 citations · Full text

, , +9

Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain

Melanie A. McGill, C. Jane McGlade · Journal of Biological Chemistry · 2003 · 459 citations · Full text

, , +14