A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang, +5

Nature

Insulin ResistanceMetabolic SyndromeObesityMetabolic DisorderInsulin Management +8

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda, +3

Cell

InflammationRedox SignalingSignal TransductionApoptosisImmunology +10

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Zuoning Han, David L. Boyle, Lufen Chang, +5

Journal of Clinical Investigation

Metalloproteinase ExpressionImmunologyPathologyCell DeathJoint Destruction +23

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Lufen Chang, Hideaki Kamata, Giovanni Solinas, +5

Cell

Signal TransductionC-flipl TurnoverSignaling PathwayCell RegulationMedicine +7

Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

Toshiharu Sakurai, Shin Maeda, Lufen Chang, +1

Proceedings of the National Academy of Sciences

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

Wen-Ming Chu, Derek Ostertag, Zhi-Wei Li, +6

Immunity

Host ResponseSignal TransductionPathogenesisImmunologyViral Pathogenesis +13

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

Lufen Chang, Ying Jones, Mark H. Ellisman, +2

Developmental Cell

Cell PhysiologyProtein FunctionSignal TransductionMolecular NeuroscienceControls Phosphorylation +11

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2

Kanaga Sabapathy, Wolfram Jochum, Konrad Hochedlinger, +3

Mechanisms of Development

Molecular NeuroscienceDevelopmental BiologyEpendymaCell SignalingApoptosis +9

Functional <i>in vivo</i> interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, +3

Proceedings of the National Academy of Sciences

Metabolic DisorderMetabolic RemodelingTotal Jnk ActivityInsulin SignalingOxidative Stress +20

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

Shin Maeda, Lufen Chang, Zhiwei Li, +3

Immunity

InflammationCytokineSignal TransductionSignaling PathwayMedicine +10