Lufen Chang

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Insulin Resistance, Metabolic Syndrome, Obesity +10

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Hideaki Kamata, Shinichi Honda, Shin Maeda et al. · Cell · 2005 · 1.8K citations · Full text

Inflammation, Redox Signaling, Signal Transduction +12

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Zuoning Han, David L. Boyle, Lufen Chang et al. · Journal of Clinical Investigation · 2001 · 771 citations · Full text

Metalloproteinase Expression, Immunology, Pathology +25

The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Lufen Chang, Hideaki Kamata, Giovanni Solinas et al. · Cell · 2006 · 687 citations · Full text

Signal Transduction, C-flipl Turnover, Signaling Pathway +9

Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation

Toshiharu Sakurai, Shin Maeda, Lufen Chang et al. · Proceedings of the National Academy of Sciences · 2006 · 403 citations · Full text