The E3 Ubiquitin Ligase Itch Couples JNK Activation to TNFα-induced Cell Death by Inducing c-FLIPL Turnover

Lufen Chang, Hideaki Kamata, Giovanni Solinas, +5

Cell

Signal TransductionC-flipl TurnoverSignaling PathwayCell RegulationMedicine +7

JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity

Giovanni Solinas, Cristian Vilcu, Jaap G. Neels, +8

Cell Metabolism

ObesityMetabolic SyndromeInflammationInsulin ResistanceHematopoietically Derived Cells +10

Functional <i>in vivo</i> interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance

Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, +3

Proceedings of the National Academy of Sciences

Metabolic DisorderMetabolic RemodelingTotal Jnk ActivityInsulin SignalingOxidative Stress +20

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

Giovanni Solinas, Willscott E. Naugler, Francesco Galimi, +2

Proceedings of the National Academy of Sciences

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

Ryan G. Holzer, EekJoong Park, Ning Li, +5

Cell

Proteinlipid InteractionSignal TransductionBiochemistryMembrane SubdomainsMedicine +6

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

John L. Stebbins, Surya K. De, Thomas Machleidt, +10

Proceedings of the National Academy of Sciences

Jnk-jip Interaction SiteInsulin SignalingSignaling PathwayJnk-interacting Protein-1Cell Signaling +17

Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study

Emanuel Fryk, Josefin Olausson, Karin Mossberg, +10

EBioMedicine

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

Giovanni Solinas, Serge Summermatter, Davide Mainieri, +7

FEBS Letters

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

Angela Molinaro, Barbara Becattini, Arianna Mazzoli, +7

Cell Metabolism

Insulin-driven Pi3k-akt SignalingSignal TransductionMolecular PhysiologyPi3kβ ActivitiesSignaling Pathway +8

Leptin directly stimulates thermogenesis in skeletal muscle

Abdul G. Dulloo, Michael J. Stock, Giovanni Solinas, +3

FEBS Letters