NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Claudio Mauro, Shi Chi Leow, Elena Ansó, +9

Nature Cell Biology

Energy HomeostasisEnergy MetabolismMitochondrial FunctionMitochondrial DynamicPhysiology +11

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

Lucia Di Marcotullio, Azzura Greco, Daniela Mazzà, +9

Oncogene

Signal TransductionNovel Degradation SignalSignaling PathwayMolecular RegulationG Protein-coupled Receptor +7

Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma

Enrico De Smaele, Lucia Di Marcotullio, Marta Moretti, +14

Neoplasia

Kctd ContainingChromatinDevelopmental BiologySignaling PathwayGlioma +9

Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Sonia Coni, Silvia Maria Serrao, Zuleyha Nihan Yurtsever, +17

Cell Death and Disease

Molecular organization of the cullin E3 ligase adaptor KCTD11

Stefania Correale, Luciano Pirone, Lucia Di Marcotullio, +9

Biochimie

Protein AssemblyNatural SciencesMolecular BiologyBiomolecular InteractionMolecular Organization +1

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

Laura Di Magno, Simona Manni, Fiorella Di Pastena, +18

Cell Reports

An Integrated Approach Identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated Genes in Developing Cerebellum and Medulloblastoma

Enrico De Smaele, Caterina Fragomeli, Elisabetta Ferretti, +13

Neoplasia

GeneticsCancer BiologyGene Expression ProfilingSonic HedgehogTumor Biology +15

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

Francesca Bufalieri, Paola Infante, Flavia Bernardi, +24

Nature Communications

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells

Agnese Pò, Anna Citarella, Giuseppina Catanzaro, +9

Scientific Reports

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

Ludovica Lospinoso Severini, Deborah Quaglio, Irene Basili, +12

Cancers