Concepedia

Numb Proteins

Numb Proteins is an endocytic adaptor protein that functions as a cell fate determinant by mediating vesicular trafficking of transmembrane receptors through its phosphotyrosine-binding domain and distinctive capacity to asymmetrically localize during cell division.

241

Publications

19.5K

Citations

1.2K

Authors

453

Institutions

Publications per year

2017–2026

54

Variants

Numb Protein

Parents

Publications

241

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

Michelle S. Rhyu, Lily Yeh Jan, Yuh Nung Jan · Cell · 1994 · 768 citations

, , +12

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

Ming Guo, Lily Yeh Jan, Yuh Nung Jan · Neuron · 1996 · 673 citations · Full text

, , +12

Aberrant Activation of Notch Signaling in Human Breast Cancer

Spyros Stylianou, Robert B. Clarke, Keith Brennan · Cancer Research · 2006 · 557 citations

, , +14

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

Tadashi Uemura, Susan Shepherd, Larry Ackerman et al. · Cell · 1989 · 512 citations

, , +15

Asymmetric segregation of Numb and Prospero during cell division

Juergen A. Knoblich, Lily Yeh Jan, Yuh Nung Jan · Nature · 1995 · 501 citations

, , +12

1–5 of 241

Authors

1.2K

  1. YN
    Yuh Nung Jan

    Howard Hughes Medical Institute, United States

    19 publications · 5.2K citations

    19

    h-index

  2. LY
    Lily Yeh Jan

    Howard Hughes Medical Institute, United States

    17 publications · 4.8K citations

    17

    h-index

  3. CJ
    C. Jane McGlade

    University of Toronto, Canada

    15 publications · 1.5K citations

    15

    h-index

  4. WZ
    Weimin Zhong

    Yale University, United States

    11 publications · 1.8K citations

    11

    h-index

  5. JM
    Joseph M. Verdi

    Maine Medical Center Research Institute, United States

    7 publications · 537 citations

    7

    h-index

1–5 of 1.2K

Institutions

453

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    24 h-index

    79 publications

    19K citations

  2. University of California, San Francisco

    San Francisco, United States

    18 h-index

    63 publications

    16.3K citations

  3. University of Toronto

    Toronto, Canada

    18 h-index

    66 publications

    7.9K citations

  4. Hospital for Sick Children

    Toronto, Canada

    17 h-index

    56 publications

    6.7K citations

  5. Yale University

    New Haven, United States

    11 h-index

    43 publications

    7.5K citations

  6. SickKids Foundation

    Toronto, Canada

    11 h-index

    29 publications

    3.6K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    21 publications

    1.8K citations

  8. Western University

    London, Canada

    8 h-index

    41 publications

    3.4K citations

1–8 of 453

Venues

  1. Journal of Biological Chemistry

    JBC · 15 publications · 1.1K citations

    15

    h-index

  2. Development

    11 publications · 1.1K citations

    11

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 1.1K citations

    10

    h-index

  4. PLoS ONE

    8 publications · 262 citations

    8

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 7 publications · 170 citations

    7

    h-index

1–5