Application and Validation of an Advanced Gastrointestinal In Vitro Model for the Evaluation of Drug Product Performance in Pharmaceutical Development

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +16

A Dynamic Artificial Gastrointestinal System for Studying the Behavior of Orally Administered Drug Dosage Forms Under Various Physiological Conditions

S. Blanquet, Evelijn Zeijdner, Erick Beyssac et al. · Pharmaceutical Research · 2004 · 276 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans

Win L. Chiou, Hyun Y. Jeong, Sang M. Chung et al. · Pharmaceutical Research · 2000 · 182 citations

Pharmacy, Pharmacokinetics, Pharmacology +11

Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1)

David Ribnicky, Diana E. Roopchand, Andrew Oren et al. · Food Chemistry · 2013 · 177 citations

Agriculture, Food Science, Nutritional Sciences +17

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Erik Sjögren, Jan Westergren, Iain Grant et al. · European Journal of Pharmaceutical Sciences · 2013 · 167 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +16