Concepedia

Intestinal Bioavailability

Intestinal Bioavailability is the fraction of an orally administered drug that reaches systemic circulation intact after undergoing pre-systemic metabolism in the intestinal wall, distinguishing it from hepatic first-pass effects by specifically accounting for enterocyte-mediated biotransformation and efflux transporter activity.

597

Publications

32.3K

Citations

2.8K

Authors

767

Institutions

Publications per year

2017–2026

105

Parents

Publications

597

Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

Guido Shoba, David C. Joy, Thangam Joseph et al. · Planta Medica · 1998 · 1.9K citations

, , +13

Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies

Lida Kalantzi, Konstantinos Goumas, V. Kalioras et al. · Pharmaceutical Research · 2005 · 653 citations

, , +14

Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability

Kenneth D.R. Setchell, Nadine M. Brown, Linda Zimmer-Nechemias et al. · American Journal of Clinical Nutrition · 2002 · 618 citations · Full text

, , +9

Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Yitong Liu, Haiping Hao, Hong‐Guang Xie et al. · Drug Metabolism and Disposition · 2010 · 339 citations

, , +17

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles J. Rotter et al. · Journal of Medicinal Chemistry · 2010 · 325 citations

, , +16

1–5 of 597

Authors

2.8K

  1. PA
    Patrick Augustijns

    KU Leuven, Belgium

    13 publications · 766 citations

    13

    h-index

  2. JB
    Joachim Brouwers

    KU Leuven, Belgium

    10 publications · 606 citations

    10

    h-index

  3. HL
    Hans Lennernäs

    Uppsala University, Sweden

    9 publications · 527 citations

    9

    h-index

  4. JT
    Jan Tack

    KU Leuven, Belgium

    7 publications · 426 citations

    7

    h-index

  5. SY
    Shinji Yamashita

    Setsunan University, Japan

    7 publications · 202 citations

    7

    h-index

1–5 of 2.8K

Institutions

767

  1. KU Leuven

    Leuven, Belgium

    14 h-index

    55 publications

    3.2K citations

  2. Uppsala University

    Uppsala, Sweden

    14 h-index

    32 publications

    2.1K citations

  3. Kyoto Pharmaceutical University

    Kyoto, Japan

    10 h-index

    42 publications

    1.1K citations

  4. China Pharmaceutical University

    Nanjing, China

    10 h-index

    45 publications

    3.3K citations

  5. AstraZeneca (Sweden)

    Södertälje, Sweden

    9 h-index

    33 publications

    6K citations

  6. Setsunan University

    Osaka, Japan

    9 h-index

    38 publications

    1.1K citations

  7. Wageningen University & Research

    Wageningen, The Netherlands

    8 h-index

    26 publications

    1.7K citations

  8. University of Michigan

    Ann Arbor, United States

    8 h-index

    16 publications

    615 citations

1–8 of 767

Venues

  1. Drug Metabolism and Disposition

    23 publications · 1.7K citations

    20

    h-index

  2. PubMed

    Repository · 26 publications · 1.2K citations

    19

    h-index

  3. Pharmaceutical Research

    24 publications · 1.7K citations

    19

    h-index

  4. International Journal of Pharmaceutics

    19 publications · 1.1K citations

    17

    h-index

  5. Journal of Pharmacy and Pharmacology

    JPP · 20 publications · 890 citations

    15

    h-index

1–5