Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

Weijia Kong, Jing Wei, Parveen Abidi et al. · Nature Medicine · 2004 · 1.4K citations

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The anti-inflammatory potential of berberine in vitro and in vivo

Chi-Li Kuo, Chin‐Wen Chi, Tsung‐Yun Liu · Cancer Letters · 2003 · 684 citations

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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Hao Zhang, Jing Wei, Rong Xue et al. · Metabolism · 2009 · 433 citations

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Berberine sulfate: antimicrobial activity, bioassay, and mode of action

AR Amin, T. V. Subbaiah, Kobra Abbasi · Canadian Journal of Microbiology · 1969 · 297 citations

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Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

Feng Zuo, Norio Nakamura, Teruaki Akao et al. · Drug Metabolism and Disposition · 2006 · 281 citations

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