Charles J. Rotter

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles J. Rotter et al. · Journal of Medicinal Chemistry · 2010 · 314 citations

Nutrition, Pharmaceutical Science, Oral Bioavailability +19

Development of a new permeability assay using low‐efflux MDCKII cells

Li Di, Carrie Whitney‐Pickett, John P. Umland et al. · Journal of Pharmaceutical Sciences · 2011 · 311 citations

Membrane Transport, Membrane Biology, Biomedical Engineering +6

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Manthena V. S. Varma, Iain Gardner, Stefanus J. Steyn et al. · Molecular Pharmaceutics · 2012 · 163 citations

Pharmaceutical Science, Permeability Criteria, Physiologically-based Pharmacokinetic Modeling +27

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

Daniel S. Nielsen, Huy N. Hoang, Rink‐Jan Lohman et al. · Angewandte Chemie International Edition · 2014 · 138 citations

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

Arthur C Rand, Siegfried S. F. Leung, Heather Eng et al. · MedChemComm · 2012 · 131 citations