Iain Gardner

Modelling and PBPK Simulation in Drug Discovery

Hannah M. Jones, Iain Gardner, Kenny J. Watson · The AAPS Journal · 2009 · 198 citations · Full text

Engineering, Pharmacokinetic Modeling, Medicine +5

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

Stéphane Berghmans, Paul Butler, Paul Goldsmith et al. · Journal of Pharmacological and Toxicological Methods · 2008 · 187 citations

Animal Testing, Preclinical Drug Evaluation, Medicine +8

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Manthena V. S. Varma, Iain Gardner, Stefanus J. Steyn et al. · Molecular Pharmaceutics · 2012 · 163 citations

Pharmaceutical Science, Permeability Criteria, Physiologically-based Pharmacokinetic Modeling +27

A Comparison of the Covalent Binding of Clozapine and Olanzapine to Human Neutrophils In Vitro and In Vivo

Iain Gardner, J. Steven Leeder, Nasir Zahid et al. · Molecular Pharmacology · 1998 · 118 citations

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

Hannah M. Jones, Iain Gardner, Wendy T. Collard et al. · Clinical Pharmacokinetics · 2011 · 111 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modelling, Pharmacodynamics +10