Stefanus J. Steyn

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

Manthena V. S. Varma, R. Scott Obach, Charles J. Rotter et al. · Journal of Medicinal Chemistry · 2010 · 325 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

Manthena V. S. Varma, Stefanus J. Steyn, Charlotte Allerton et al. · Pharmaceutical Research · 2015 · 311 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

João Paulo Lima Daher, Hisham Abdelmotilib, Xianzhen Hu et al. · Journal of Biological Chemistry · 2015 · 210 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward et al. · Journal of Medicinal Chemistry · 2014 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Manthena V. S. Varma, Iain Gardner, Stefanus J. Steyn et al. · Molecular Pharmaceutics · 2012 · 164 citations

Pharmacy, Pharmacokinetics, Pharmacology +17