Concepedia

The challenge of using read-across within the EU REACH regulatory framework; how much uncertainty is too much? Dipropylene glycol methyl ether acetate, an exemplary case study

Nicholas Ball, Michael Bartels, Robert A. Budinsky, Joanna Klapacz, Sean M. Hays, Christopher R. Kirman, Grace Patlewicz

Regulatory Toxicology and Pharmacology · 2014 · 57 citations · 27 references

DOI

Concepts

References

27

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

Robert J. Riley, Dermot F. McGinnity, Rupert P. Austin · Drug Metabolism and Disposition · 2005 · 370 citations

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Esterase Activity Able To Hydrolyze Dietary Antioxidant Hydroxycinnamates Is Distributed along the Intestine of Mammals

Mette Findal Andreasen, Paul A. Kroon, Gary Williamson et al. · Journal of Agricultural and Food Chemistry · 2001 · 298 citations

, , +13

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

Costanza Rovida · ALTEX · 2009 · 259 citations · Full text

, , +13

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

David Hallifax, Joanne Foster, J. Brian Houston · Pharmaceutical Research · 2010 · 195 citations

, , +12

Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats

R R Miller, Emile A. Hermann, Patrick W. Langvardt et al. · Toxicology and Applied Pharmacology · 1983 · 168 citations

, , +7