Concepedia

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

Haiyan Huang, H Wang, Michael Sinz, Mary Zoeckler, Jeff L. Staudinger, Matthew R. Redinbo, Denise G. Teotico, Joseph Locker, Ganjam V. Kalpana, Sridhar Mani

Oncogene · 2006 · 209 citations · 40 references

DOI

Concepts

References

40

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

, , +13

Vitamin D Receptor As an Intestinal Bile Acid Sensor

Makoto Makishima, Timothy T. Lu, Wen Xie et al. · Science · 2002 · 1.2K citations

, , +17

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 920 citations · Full text

, , +17

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

Timothy W. Synold, Isabelle Dussault, Barry M. Forman · Nature Medicine · 2001 · 834 citations

, , +11