Sridhar Mani

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vétizou, Jonathan M. Pitt, Romain Daillère et al. · Science · 2015 · 3.3K citations · Full text

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Bret D. Wallace, Hongwei Wang, Kimberly T. Lane et al. · Science · 2010 · 996 citations

Chemoprevention Strategy, Gastrointestinal Pharmacology, Antibiotic Adjuvant +19

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

Madhukumar Venkatesh, Subhajit Mukherjee, Hongwei Wang et al. · Immunity · 2014 · 955 citations · Full text

Xenobiotic Sensor Pxr, Dysbiosis, Mucosal Immunology +11

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Samantha M. Ervin, Hao Li, Lauren Lim et al. · Journal of Biological Chemistry · 2019 · 340 citations · Full text

Biosynthesis, Biochemistry, Endocrine Research +15

The gut metabolite indole-3 propionate promotes nerve regeneration and repair

Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica Chadwick et al. · Nature · 2022 · 331 citations

Regenerative Medicine, Neuroregeneration, Developmental Biology +8