Optimization of the Secondary Drying Step in Freeze Drying Using TDLAS Technology

The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

Michael J. Pikal, Karen M. Dellerman, and Michael L. Roy et al. · Pharmaceutical Research · 1991 · 273 citations

Effect of Moisture on the Stability of a Lyophilized Humanized Monoclonal Antibody Formulation

E. D. Breen, J. G. Curley, David E. Overcashier et al. · Pharmaceutical Research · 2001 · 187 citations

Evaluation of tunable diode laser absorption spectroscopy for in‐process water vapor mass flux measurements during freeze drying

Henning Gieseler, William J. Kessler, Michael L. Finson et al. · Journal of Pharmaceutical Sciences · 2007 · 136 citations

Engineering, Desiccation, Spectroscopy +5

Rapid Determination of Vial Heat Transfer Parameters Using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Response to Step-Changes in Pressure Set-Point During Freeze-Drying

Wei Y. Kuu, Steven L. Nail, Gregory A. Sacha · Journal of Pharmaceutical Sciences · 2008 · 87 citations

Heat Transfer Process, Engineering, Rapid Determination +10

Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. correlation of protein–sugar interaction with native structure preservation

Bingquan Wang, Serguei Tchessalov, Nicholas W. Warne et al. · Journal of Pharmaceutical Sciences · 2008 · 74 citations

Native Structure Preservation, Protein Chemistry, Biochemistry +7