Gregory A. Sacha

Rapid Determination of Vial Heat Transfer Parameters Using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Response to Step-Changes in Pressure Set-Point During Freeze-Drying

Wei Y. Kuu, Steven L. Nail, Gregory A. Sacha · Journal of Pharmaceutical Sciences · 2008 · 87 citations

Heat Transfer Process, Engineering, Rapid Determination +10

Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study

Linas Mockus, Timothy W. Paul, Nathan A. Pease et al. · Pharmaceutical Development and Technology · 2011 · 51 citations

Thermal Analysis of Frozen Solutions: Multiple Glass Transitions in Amorphous Systems

Gregory A. Sacha, Steven L. Nail · Journal of Pharmaceutical Sciences · 2009 · 49 citations

Materials Science, Multiple Glass Transitions, Engineering +8

Recommended Best Practices for Lyophilization Validation—2021 Part I: Process Design and Modeling

Feroz Jameel, Alina Alexeenko, Akhilesh Bhambhani et al. · AAPS PharmSciTech · 2021 · 25 citations · Full text

Engineering, Industrial Engineering, Mechanical Engineering +24

Identification of Physical-Chemical Variables Affecting Particle Size Following Precipitation Using a Supercritical Fluid

Gregory A. Sacha, W. Schmitt, Steven L. Nail · Pharmaceutical Development and Technology · 2006 · 23 citations

Engineering, Supercritical Fluid Chromatography, Fluid Mechanics +20