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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Hcv Ns5b PolymeraseBiochemistryNatural SciencesAntiviral Drug DevelopmentMolecular BiologyAntiviral DrugTetracyclic Indole-based MacrocycleAntiviral CompoundDrug DiscoveryPart Ii