Concepedia

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Sandrine Vendeville, Tse‐I Lin, Lili Hu, Abdellah Tahri, David C. McGowan, Maxwell D. Cummings, Katie Amssoms, Maxime Canard, Stefaan Last, Iris Van den Steen,

Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations · 16 references

DOI

Concepts

References

16

Diagnosis, management, and treatment of hepatitis C†

Doris B. Strader, Teresa L. Wright, David L. Thomas et al. · Hepatology · 2004 · 1.7K citations

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Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.

Sven‐Erik Behrens, Licia Tomei, Raffaele De Francesco · The EMBO Journal · 1996 · 685 citations · Full text

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Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity

Volker Lohmann, Frank Körner, Ulrike Herian et al. · Journal of Virology · 1997 · 516 citations · Full text

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A 10-Year Experience of Liver Transplantation for Hepatitis C: Analysis of Factors Determining Outcome in Over 500 Patients

Rafik M. Ghobrial, Randy Steadman, Jeffery Gornbein et al. · Annals of Surgery · 2001 · 244 citations

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In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse‐I Lin, Oliver Lenz, Gregory Fanning et al. · Antimicrobial Agents and Chemotherapy · 2009 · 190 citations · Full text

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