Stefaan Last

Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase

Koen Vandyck, Maxwell D. Cummings, Origène Nyanguile et al. · Journal of Medicinal Chemistry · 2009 · 60 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus

David C. McGowan, Florence Herschke, Frederik Pauwels et al. · Journal of Medicinal Chemistry · 2016 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Sandrine Vendeville, Tse‐I Lin, Lili Hu et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 39 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Maxwell D. Cummings, Tse‐I Lin, Lili Hu et al. · Journal of Medicinal Chemistry · 2013 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure‐Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Maxwell D. Cummings, Tse‐I Lin, Lili Hu et al. · Angewandte Chemie International Edition · 2012 · 37 citations

Medicine, Medicinal Chemistry, Pharmacology +14