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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Wenyu Yu, Emma J. Chory, Amy K. Wernimont, W. Tempel, Alex Scopton, Alexander Federation, Jason Marineau, Jun Qi, Dalia Baršytė-Lovejoy, Richard Marcellus,

Nature Communications · 2012 · 286 citations · 22 references

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22

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Cancer Cell · 2011 · 934 citations · Full text

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MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

Kathrin M. Bernt, Nan Zhu, Amit Sinha et al. · Cancer Cell · 2011 · 893 citations · Full text

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Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain

Qin Feng, Hengbin Wang, Huck‐Hui Ng et al. · Current Biology · 2002 · 855 citations

, , +12

Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Önder, Nergis Kara, Anne Cherry et al. · Nature · 2012 · 637 citations

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Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

Robert K. McGinty, Jaehoon Kim, Champak Chatterjee et al. · Nature · 2008 · 567 citations

, , +11