The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores

“Mini-mental state”

Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research · 1975 · 85.9K citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

Ephrat Levy‐Lahad, Wilma Wasco, Parvoneh Poorkaj et al. · Science · 1995 · 2.6K citations

Alzheimer's Disease, Genetic Disorder, Genetics +12

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Robin Sherrington, Ekaterina Rogaeva, Georges Lévesque et al. · Nature · 1995 · 2.1K citations

Disease Heterogeneity, Alzheimer's Disease, Mendelian Disorder +10

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

Marc Freichel, Suk Hyo Suh, Alexander Pfeifer et al. · Nature Cell Biology · 2001 · 569 citations

Molecular Pharmacology, Signal Transduction, Molecular Physiology +13

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Qing Guo, Weiming Fu, Bryce L. Sopher et al. · Nature Medicine · 1999 · 490 citations

Molecular Neuroscience, Cell Death, Neuroprotection +7