E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation

Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization

D Grail, G. S. Hodgson, D Metcalf et al. · Blood · 1994 · 945 citations · Full text

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Markus Welcker, Amir Orian, Jianping Jin et al. · Proceedings of the National Academy of Sciences · 2004 · 928 citations · Full text

Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7

Masayoshi Yada, Shigetsugu Hatakeyama, Takumi Kamura et al. · The EMBO Journal · 2004 · 807 citations · Full text

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama et al. · Nature · 2011 · 628 citations · Full text

Signaling Pathway, Cell Regulation, Apoptosis +6

Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

Stephen Orlicky, Xiaojing Tang, Andrew Willems et al. · Cell · 2003 · 503 citations

Phosphodependent Substrate Selection, Biochemistry, Structural Bioinformatics +7