Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency - Concepedia

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Publication | Open Access

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency

DOI Full Paper Access

133

Citations

26

References

2012

Year

A. Ordóñez, Erik L. Snapp, Lu Tan, Elena Miranda, Stefan J. Marciniak, David A. Lomas

Abstract

Changes in protein diffusion provide an explanation for the cellular consequences of ER protein overload in mutants that cause inclusion body formation and α1AT deficiency.

References

	Year	Citations
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+ Martin D. Bootman, Ludwig Missiaen, Jan B. Parys, Biochemical Journal	1995	5.1K
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum Stefan J. Marciniak, Chi Young Yun, Seiichi Oyadomari, Genes & Development Er OxidaseLipid PeroxidationApoptosisCell DeathEr Stress	2004	2K
The mechanism of Z α1-antitrypsin accumulation in the liver David A. Lomas, Dyfed LI-Evans, J.T. Finch, Nature HepatologyMedicineLiver PhysiologyPhysiologyZ α1-Antitrypsin Accumulation	1992	1K
Orchestrating the unfolded protein response in health and disease Randal J. Kaufman Journal of Clinical Investigation	2002	995
An Autophagy-Enhancing Drug Promotes Degradation of Mutant α <sub>1</sub> -Antitrypsin Z and Reduces Hepatic Fibrosis Tunda Hidvegi, Michael Ewing, Pamela Hale, Science	2010	593
Familial dementia caused by polymerization of mutant neuroserpin Richard L. Davis, Antony E. Shrimpton, P D Holohan, Nature Alzheimer's DiseaseDementiaFrontotemporal DementiaNeuroscienceNeurology	1999	347
A lag in intracellular degradation of mutant alpha 1-antitrypsin correlates with the liver disease phenotype in homozygous PiZZ alpha 1-antitrypsin deficiency. Yu‐Ling Wu, I. P. Whitman, Ernesto P. Molmenti, Proceedings of the National Academy of Sciences Common Er DegradationImmunologyPathologyAsialoglycoprotein Receptor SubunitsProtein Expression	1994	291
The Natural History of Liver Disease in (α<sub>1</sub>‐Antitrypsin Deficient Children Tomas Sveger Acta Paediatrica PathologyFatty Liver DiseaseCholangiopathiesHepatic DisordersSwedish Infants	1988	242
Accumulation of Mutant α1-Antitrypsin Z in the Endoplasmic Reticulum Activates Caspases-4 and -12, NFκB, and BAP31 but Not the Unfolded Protein Response Tunda Hidvegi, Béla Z. Schmidt, Pamela Hale, Journal of Biological Chemistry ImmunologyCell DeathCellular PhysiologySignaling PathwayAutophagy	2005	237
Calcium-Induced Restructuring of Nuclear Envelope and Endoplasmic Reticulum Calcium Stores Kala Subramanian, Tobias Meyer Cell Signal TransductionMolecular BiologyNuclear EnvelopeProtein TransportIntracellular Trafficking	1997	232

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