Orchestrating the unfolded protein response in health and disease

Abstract

Nonstandard abbreviations used: endoplasmic reticulum (ER); unfolded protein response (UPR); basic leucine zipper (bZIP); UPR element (UPRE); endoplasmic reticulum stress response element (ERSE); site-1 protease (S1P); site-2 protease (S2P); sterol-response element-binding protein (SREBP); eukaryotic translation initiation factor 2 (eIF2); endoplasmic reticulum-associated degradation (ERAD); 1-proteinase