Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell · 2007 · 20.2K citations

Life Sciences, Cell Biology, Developmental Biology +12

Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

Eberhard Scherzinger, Rudi Lurz, Mark Turmaine et al. · Cell · 1997 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +10

Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract

Cheryl L. Wellington, Lisa Ellerby, Abigail S. Hackam et al. · Journal of Biological Chemistry · 1998 · 568 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Expanded polyglutamine in the Machado–Joseph disease protein induces cell death in vitro and in vivo

Hanako Ohashi Ikeda, Masahiro Yamaguchi, Satoshi Sugai et al. · Nature Genetics · 1996 · 548 citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

Songming Chen, Frank A. Ferrone, Ronald Wetzel · Proceedings of the National Academy of Sciences · 2002 · 527 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17