Concepedia

Novel histone deacetylase 8 ligands without a zinc chelating group: Exploring an ‘upside-down’ binding pose

Aditya S. Vaidya, Raghupathi Neelarapu, Antonett Madriaga, He Bai, Emma Mendonca, Hazem Abdelkarim, Richard B. van Breemen, Sylvie Y. Blond, Pavel A. Petukhov

Bioorganic & Medicinal Chemistry Letters · 2012 · 22 citations · 24 references

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24

Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

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HDAC2 negatively regulates memory formation and synaptic plasticity

Ji‐Song Guan, Stephen J. Haggarty, Emanuela Giacometti et al. · Nature · 2009 · 1.6K citations · Full text

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

, , +16

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

Nagma Khan, Michael Jeffers, Sampath Kumar et al. · Biochemical Journal · 2007 · 710 citations · Full text

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Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 698 citations · Full text

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