Concepedia

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki, Kaori Watanabe, Misaki Sekiguchi, Emi Hosoki, Maho Kawashima-Morishima, Hahn-Jun Lee, Emi Hama, Yoko Sekine‐Aizawa,

Nature Medicine · 2000 · 862 citations · 22 references

DOI

Concepts

References

22

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

, , +17

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Karen Duff, Chris Eckman, Cindy Zehr et al. · Nature · 1996 · 1.5K citations

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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Wei Qiao Qiu, Dominic M. Walsh, Zhen Ye et al. · Journal of Biological Chemistry · 1998 · 800 citations · Full text

, , +17