Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

Salvatore Valitutti, Sabina Müller, Marina Cella et al. · Nature · 1995 · 1.1K citations

Life Sciences, Immunology, Molecular Biology +16

Evidence for a differential avidity model of T cell selection in the thymus

Philip G. Ashton‐Rickardt, António Bandeira, Joseph R. Delaney et al. · Cell · 1994 · 665 citations

Life Sciences, Cell Biology, Immunology +12

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

Clifford V. Harding, Emil R. Unanue · Nature · 1990 · 458 citations

Life Sciences, Cell Biology, Immunology +11

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

Kouhei Matsui, J. Jay Boniface, P Steffner et al. · Proceedings of the National Academy of Sciences · 1994 · 422 citations

Life Sciences, Immunology, Molecular Biology +17

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

Stéphane Demotz, Howard M. Grey, Alessandro Sette · Science · 1990 · 399 citations

Life Sciences, Cell Biology, Immunology +17