6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

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Medicine, Medicinal Chemistry, Pharmacology +15

Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism

Nathalie Breysse, Christelle Baunez, Will Spooren et al. · Journal of Neuroscience · 2002 · 177 citations · Full text

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Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4???Tesla

K. Luan Phan, Daniel A. Fitzgerald, Bernadette M. Cortese et al. · Neuroreport · 2005 · 94 citations

Nursing, Neuroscience, Psychiatry +13

Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH‐impedance study in healthy subjects

Frank Zerbib, Charlotte Keywood, Grégory Strabach · Neurogastroenterology & Motility · 2010 · 44 citations

Medicine, Pharmacokinetics, Pharmacology +15

Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists

Jeffrey P. Lamb, Darren W. Engers, Colleen M. Niswender et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17