Concepedia

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

James A. Dykens, Joseph Jamieson, Lisa D. Marroquin, Sashi Nadanaciva, Puja Billis, Yvonne Will

Toxicology and Applied Pharmacology · 2008 · 222 citations · 25 references

DOI

Concepts

References

25

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

Lisa D. Marroquin, James T. Hynes, James A. Dykens et al. · Toxicological Sciences · 2007 · 639 citations

, , +17

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

Barbara Brunmair, Katrin Staniek, Nicole Scharf et al. · Diabetes · 2004 · 518 citations · Full text

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 395 citations

, , +17

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Xu Huang, Stephan Wullschleger, Natalia Shpiro et al. · Biochemical Journal · 2008 · 393 citations · Full text

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