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Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers

Michael T. Rudd, Charles McIntyre, Joseph J. Romano, John W. Butcher, M. Katharine Holloway, Kimberly J. Bush, Kevin T. Nguyen, Kevin F. Gilbert, Terry A. Lyle, Nigel J. Liverton,

Bioorganic & Medicinal Chemistry Letters · 2012 · 11 citations · 15 references

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15

Peginterferon-α2a and Ribavirin Combination Therapy in Chronic Hepatitis C

Stephanos J. Hadziyannis · Annals of Internal Medicine · 2004 · 2.8K citations

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Daniel Lamarre, Paul C. Anderson, Murray D. Bailey et al. · Nature · 2003 · 913 citations

, , +15

Side effects of therapy of hepatitis C and their management

Michael Fried · Hepatology · 2002 · 556 citations · Full text

, , +17

Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease

Robert B. Perni, Susan J. Almquist, Randal A. Byrn et al. · Antimicrobial Agents and Chemotherapy · 2006 · 387 citations · Full text

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MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Vincenzo Summa, Steven W. Ludmerer, John A. McCauley et al. · Antimicrobial Agents and Chemotherapy · 2012 · 255 citations · Full text

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