Concepedia

Macrocyclic Library Design

Macrocyclic Library Design is a combinatorial chemistry methodology that systematically generates structurally diverse macrocyclic compound libraries by employing ring-closing strategies to explore three-dimensional chemical space for drug discovery applications.

377

Publications

14.4K

Citations

1.8K

Authors

445

Institutions

Publications per year

2017–2026

77

Parents

Publications

377

Combinatorial synthesis — the design of compound libraries and their application to drug discovery

N.K. Terrett, Mark Gardner, David W. Gordon et al. · Tetrahedron · 1995 · 657 citations

, , +16

Concise Synthesis and Crystal Structure of [12]Cycloparaphenylene

Yasutomo Segawa, Shinpei Miyamoto, Haruka Omachi et al. · Angewandte Chemie International Edition · 2011 · 239 citations

, , +13

Total Syntheses of (+)-Zampanolide and (+)-Dactylolide Exploiting a Unified Strategy

Amos B. Smith, Igor G. Safonov, R. Michael Corbett · Journal of the American Chemical Society · 2002 · 172 citations

, , +14

Designing Large Triangular Chiral Macrocycles:  Efficient [3 + 3] Diamine−Dialdehyde Condensations Based on Conformational Bias

Jacek Gawroński, Halina Kołbon, Marcin Kwit et al. · The Journal of Organic Chemistry · 2000 · 171 citations

, , +16

Giant Macrocycles Composed of Thiophene, Acetylene, and Ethylene Building Blocks

Kazumi Nakao, Masayuki Nishimura, Tomoya Tamachi et al. · Journal of the American Chemical Society · 2006 · 170 citations

, , +13

1–5 of 377

Authors

1.8K

  1. AD
    Alexander Dömlingꝉ

    University of Groningen, Netherlands

    10 publications · 323 citations

    10

    h-index

  2. AB
    Amos B. Smith

    University of Pennsylvania, United States

    9 publications · 606 citations

    9

    h-index

  3. KC
    K. C. Nicolaou

    Scripps Research Institute, United States

    8 publications · 563 citations

    8

    h-index

  4. LA
    Ludger A. Wessjohann

    Leibniz Institute of Plant Biochemistry, Germany

    8 publications · 380 citations

    8

    h-index

  5. EM
    Eman M. M. Abdelraheem

    Sohag University, Egypt

    8 publications · 277 citations

    8

    h-index

1–5 of 1.8K

Institutions

445

  1. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    77 publications

    3K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    12 h-index

    61 publications

    2.2K citations

  3. Scripps Research Institute

    San Diego, United States

    11 h-index

    38 publications

    3.5K citations

  4. University of Groningen

    Groningen, The Netherlands

    10 h-index

    36 publications

    1.2K citations

  5. University of Pennsylvania

    Philadelphia, United States

    9 h-index

    30 publications

    1.9K citations

  6. Leibniz Institute of Plant Biochemistry

    Halle, Germany

    9 h-index

    26 publications

    1.3K citations

  7. University of California San Diego

    San Diego, United States

    8 h-index

    27 publications

    2.1K citations

  8. Institut de Chimie des Substances Naturelles

    Gif-sur-Yvette, France

    8 h-index

    29 publications

    1.5K citations

1–8 of 445

Venues

  1. Organic Letters

    OL · 49 publications · 1.9K citations

    27

    h-index

  2. Chemical Communications

    ChemComm · 26 publications · 1K citations

    20

    h-index

  3. Tetrahedron Letters

    28 publications · 821 citations

    17

    h-index

  4. The Journal of Organic Chemistry

    JOC · 23 publications · 871 citations

    17

    h-index

  5. Angewandte Chemie International Edition

    18 publications · 1.3K citations

    17

    h-index

1–5