Development of the susceptibility to oral tolerance induction in infant mice administered a herbal drug, Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang)

CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

T Cell Activation, Signal Transduction, Autoimmune Disease +11

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Marina Cella, Doris Scheidegger, Kathrin Palmer-Lehmann et al. · The Journal of Experimental Medicine · 1996 · 2K citations · Full text

Cd40-cd40l Interaction, T-regulatory Cell, Immunology +18

The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction

Nobuyuki Sudo, S. Sawamura, Kazuo Tanaka et al. · The Journal of Immunology · 1997 · 1.1K citations · Full text

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

Franz Koch, Ursula Stanzl, Patricia Jennewein et al. · The Journal of Experimental Medicine · 1996 · 928 citations · Full text

Il-12 Induction, Immunology, Immunologic Mechanism +16

Peripheral deletion of antigen-reactive T cells in oral tolerance

Youhai Chen, Jun-ichi Inobe, Reinhard Marks et al. · Nature · 1995 · 785 citations

Autoimmune Disease, Allergy, T-regulatory Cell +7