Concepedia

Drug Tolerance

Drug Tolerance is a pharmacological phenomenon characterized by a diminished response to a drug following repeated or prolonged administration, despite maintenance of the same dosage regimen.

2.7K

Publications

126.6K

Citations

6.7K

Authors

1.4K

Institutions

Publications per year

2017–2026

88

Variants

Pharmacological Tolerance

Parents

Children

Publications

2.7K

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Bruno Giros, Mohamed Jaber, Sara R. Jones et al. · Nature · 1996 · 2.5K citations

, , +12

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

, , +17

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

George K. Aghajanian · Nature · 1978 · 800 citations

, , +14

BIOCHEMICAL AND PHARMACOLOGICAL CHANGES IN THE RAT FOLLOWING CHRONIC ADMINISTRATION OF MORPHINE, NALORPHINE AND NORMORPHINE

Joseph Cochin, Julius Axelrod · Journal of Pharmacology and Experimental Therapeutics · 1959 · 747 citations

, , +16

SIMULTANEOUS QUANTITATIVE ASSESSMENT OF MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE

E. Leong Way, Fu-Hsiung Shen · Journal of Pharmacology and Experimental Therapeutics · 1969 · 680 citations

, , +10

1–5 of 2.7K

Authors

6.7K

  1. SS
    Shepard Siegel

    McMaster University, Canada

    42 publications · 3.9K citations

    30

    h-index

  2. HK
    H. Kalant

    University of Toronto, Canada

    51 publications · 2.2K citations

    27

    h-index

  3. JK
    J.M. Khanna

    University of Toronto, Canada

    40 publications · 1.3K citations

    22

    h-index

  4. SE
    Sandra E. File

    University of London, United Kingdom

    20 publications · 1.1K citations

    18

    h-index

  5. AC
    Allan C. Collins

    University of Colorado Boulder, United States

    21 publications · 1.1K citations

    18

    h-index

1–5 of 6.7K

Institutions

1.4K

  1. University of Toronto

    Toronto, Canada

    32 h-index

    195 publications

    8.5K citations

  2. Virginia Commonwealth University Medical Center

    Richmond, United States

    26 h-index

    109 publications

    5.2K citations

  3. University of Illinois Chicago

    Chicago, United States

    26 h-index

    112 publications

    4.4K citations

  4. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    22 h-index

    93 publications

    6.3K citations

  5. Virginia Commonwealth University

    Richmond, United States

    21 h-index

    104 publications

    4.5K citations

  6. McMaster University

    Hamilton, Canada

    21 h-index

    46 publications

    4.4K citations

  7. Cornell University

    Ithaca, United States

    21 h-index

    80 publications

    8.4K citations

  8. University of Michigan

    Ann Arbor, United States

    20 h-index

    61 publications

    6K citations

1–8 of 1.4K

Venues

  1. 68

    h-index

  2. Psychopharmacology

    246 publications · 12.1K citations

    59

    h-index

  3. Pharmacology Biochemistry and Behavior

    203 publications · 6.5K citations

    43

    h-index

  4. European Journal of Pharmacology

    EJP · 145 publications · 5.9K citations

    41

    h-index

  5. PubMed

    Repository · 203 publications · 6.1K citations

    41

    h-index

1–5