Concepedia

Cerebrospinal fluid inhibits Alzheimer β‐amyloid fibril formation in vitro

Eduardo Castano, Jorge Ghiso, Blas Frangione

Annals of Neurology · 1993 · 60 citations · 15 references

DOI

Concepts

Abstract

Alzheimer's disease is characterized by the deposition of beta-protein (A beta) as amyloid. Recently, it was found that A beta is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to A beta form amyloid-like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to A beta 1-40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.

References

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