Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Life Sciences, Biochemistry, Immunology +14

Structure of 20S proteasome from yeast at 2.4Å resolution

M. Groll, Lars Ditzel, Jan Löwe et al. · Nature · 1997 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +10

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg et al. · Cell · 1994 · 2.1K citations

Life Sciences, Biochemistry, Molecular Biology +11

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +15

Crystal Structure of the 20 <i>S</i> Proteasome from the Archaeon <i>T. acidophilum</i> at 3.4 Å Resolution

Jan Löwe, Daniela Stock, Bing K. Jap et al. · Science · 1995 · 1.5K citations

Humanities, Anthropology, Archaeology +17