Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Life Sciences, Biochemistry, Molecular Biology +12

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

Life Sciences, Biochemistry, Molecular Biology +17

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

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Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

Life Sciences, Endocrinology, Physiology +17

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

Yukari Kitamura, Tadahiro Kitamura, Jan-Philipp Kruse et al. · Cell Metabolism · 2005 · 561 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14