Concepedia

Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug

Yoshinobu Yoshimura, Norio Tada, Keiji Kubo, Miwa Miyamoto, Yoshiyuki Inada, Kohei Nishikawa, Takehiko Naka

International Journal of Pharmaceutics · 1994 · 10 citations · 7 references

DOI

Concepts

References

7

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

Yumiko Shibouta, Yasuhiro Inada, M Ojima et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 213 citations

, , +13

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

Yasuhisa Kohara, Y. Yoshimura, Yumiko Shibouta et al. · Journal of Medicinal Chemistry · 1993 · 129 citations

, , +13

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

Keiji Kubo, Yoshiyuki Inada, Yasuhisa Kohara et al. · Journal of Medicinal Chemistry · 1993 · 126 citations

, , +16

Orally active 1-(cyclohexyloxycarbonyloxy)alkyl ester prodrugs of cefotiam.

Tatsuo Nishimura, Yoshinobu Yoshimura, Akio Miyake et al. · The Journal of Antibiotics · 1987 · 32 citations · Full text

, , +6

Synthesis and relationship between physicochemical properties and oral absorption of pivaloyloxymethyl esters of parenteral cephalosporins

International Journal of Pharmaceutics · 1985 · 32 citations

, , +9