Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

Frank L. Graham, W. C. Russell, James R. Smiley et al. · Journal of General Virology · 1977 · 4.9K citations

Life Sciences, Molecular Biology, Molecular Genetics +16

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Gregory J. Brewer, John R. Torricelli, E. K. Evege et al. · Journal of Neuroscience Research · 1993 · 2.3K citations

Life Sciences, Neurobiology, Neuroscience +11

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

Life Sciences, Molecular Biology, Neuroscience +15

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17