Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Medicine, Oncology, Pharmacology +12

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

Theresa M. Allen, Cecilie Cetti Hansen, Francisco J. Plaza Martín et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1991 · 1.4K citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

Hiroto Hatakeyama, Hidetaka Akita, Kentaro Kogure et al. · Gene Therapy · 2006 · 395 citations

Pharmacy, Oncology, Pharmaceutics +14

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

Jun Fang, Tomohiro Sawa, Takaaki Akaike et al. · PubMed · 2003 · 220 citations

Medicine, Oncology, Pharmacology +13

Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth

Koichi Doi, Takaaki Akaike, Shin‐ichiro Fujii et al. · British Journal of Cancer · 1999 · 181 citations · Full text

Medicine, Cancer Biology, Oncology +16