Hiroto Hatakeyama

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

Hiroto Hatakeyama, Hidetaka Akita, Kentaro Kogure et al. · Gene Therapy · 2006 · 395 citations

Pharmacy, Oncology, Pharmaceutics +14

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

Yusuke Sato, Hiroto Hatakeyama, Yu Sakurai et al. · Journal of Controlled Release · 2012 · 306 citations · Full text

Pharmacy, Molecular Biology, Pharmaceutics +14

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

Hiroto Hatakeyama, Erika Ito, Hidetaka Akita et al. · Journal of Controlled Release · 2009 · 249 citations

Life Sciences, Biotechnology, Molecular Biology +17

Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid

Hiroto Hatakeyama, Hidetaka Akita, Erika Ito et al. · Biomaterials · 2011 · 214 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +14

Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery

Golam Kibria, Hiroto Hatakeyama, Noritaka Ohga et al. · Journal of Controlled Release · 2011 · 199 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17