Concepedia

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

Yusuke Sato, Hiroto Hatakeyama, Yu Sakurai, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima

Journal of Controlled Release · 2012 · 306 citations · 33 references

DOIFull text

Open access

Concepts

References

33

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

, , +16

RNAi-mediated gene silencing in non-human primates

Tracy Zimmermann, Amy C. H. Lee, Akin Akinc et al. · Nature · 2006 · 1.3K citations

, , +8

Exploring polyethylenimine‐mediated DNA transfection and the proton sponge hypothesis

Akin Akinc, Mini Thomas, Alexander M. Klibanov et al. · The Journal of Gene Medicine · 2004 · 1.3K citations

, , +14

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

Adam D. Judge, Vandana Sood, Janet R. Shaw et al. · Nature Biotechnology · 2005 · 1.3K citations

, , +16

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg et al. · Nature Biotechnology · 2008 · 1.2K citations

, , +16