Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling

Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, +13

Proceedings of the National Academy of Sciences

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Takaaki Akaike, Tomoaki Ida, Fan‐Yan Wei, +23

Nature Communications

Activation of Matrix Metalloproteinases by Peroxynitrite-induced Protein S-Glutathiolation via Disulfide S-Oxide Formation

Tatsuya Okamoto, Takaaki Akaike, Tomohiro Sawa, +3

Journal of Biological Chemistry

Lipid PeroxidationMolecular BiologyRedox BiologyOxidative StressInflammation +14

Alkylperoxyl Radical-Scavenging Activity of Various Flavonoids and Other Phenolic Compounds:  Implications for the Anti-Tumor-Promoter Effect of Vegetables

Tomohiro Sawa, Mayumi Nakao, Takaaki Akaike, +2

Journal of Agricultural and Food Chemistry

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Motohiro Nishida, Tomohiro Sawa, Naoyuki Kitajima, +13

Nature Chemical Biology

Redox SignalingBiochemistryHydrogen Sulfide AnionRedox RegulatorRedox Chemistry +4

Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate

Tomohiro Sawa, Hasan Zaki, Tatsuya Okamoto, +9

Nature Chemical Biology

Signal TransductionBiochemistryNatural SciencesMolecular BiologyProtein S-guanylation +3

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

Jun Fang, Tomohiro Sawa, Takaaki Akaike, +5

PubMed

Ethylene GlycolChemoprevention StrategySolid TumorTumor BiologyOxidative Stress +15

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

Tatsuya Yoshizawa, Md. Fazlul Karim, Yoshifumi Sato, +19

Cell Metabolism

Systems BiologyHepatologyBiochemistryUbiquitin-proteasome PathwayNatural Sciences +10

Nitrosothiol Formation Catalyzed by Ceruloplasmin

Katsuhisa Inoue, Takaaki Akaike, Yoichi Miyamoto, +6

Journal of Biological Chemistry

Tyrosine Nitration by Peroxynitrite Formed from Nitric Oxide and Superoxide Generated by Xanthine Oxidase

Tomohiro Sawa, Takaaki Akaike, Hiroshi Maeda

Journal of Biological Chemistry