Yasuhiro Matsumura

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

Yasuhiro Matsumura, Hiroshi Maeda · PubMed · 1986 · 6.8K citations

Pathology, Cancer Biology, Cancer Chemotherapy +17

Preparation and Biological Characterization of Polymeric Micelle Drug Carriers with Intracellular pH-Triggered Drug Release Property:  Tumor Permeability, Controlled Subcellular Drug Distribution, and Enhanced in Vivo Antitumor Efficacy

Younsoo Bae, Nobuhiro Nishiyama, Shigeto Fukushima et al. · Bioconjugate Chemistry · 2004 · 731 citations

Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

Yasuhiro Matsumura, Tsuyoshi Hamaguchi, Takashi Ura et al. · British Journal of Cancer · 2004 · 614 citations · Full text

Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.

Nobuhiro Nishiyama, Souichiro Okazaki, Horacio Cabral et al. · PubMed · 2003 · 602 citations

Engineering, Solid Tumors, Biomedical Engineering +21

Tumoritropic and lymphotropic principles of macromolecular drugs.

Hiroshi Maeda, Yasuhiro Matsumura · PubMed · 1989 · 580 citations

Medicinal Chemistry, Mw 16, Drug Targeting +13