B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

Life Sciences, Immunology, Pathology +14

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

Matthew F. Krummel, James P. Allison · The Journal of Experimental Medicine · 1995 · 2.2K citations · Full text

Life Sciences, Cell Biology, Immunology +17

CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

Life Sciences, Immunology, Molecular Biology +14

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

Frederick P. Heinzel, M D Sadick, B J Holaday et al. · The Journal of Experimental Medicine · 1989 · 1.5K citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17