Concepedia

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi

Nature · 1988 · 1.7K citations · 15 references

DOI

Concepts

References

15

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

Allan Bradley, Martin Evans, M. H. Kaufman et al. · Nature · 1984 · 1.5K citations

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Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

Thomas Doetschman, Ronald G. Gregg, Nobuyo Maeda et al. · Nature · 1987 · 792 citations

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High frequency targeting of genes to specific sites in the mammalian genome

Kelly Thomas · Cell · 1986 · 629 citations

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Patterns of Integration of DNA Microinjected into Cultured Mammalian Cells: Evidence for Homologous Recombination Between Injected Plasmid DNA Molecules

Kim R. Folger, Eric A. Wong, Geoffrey M. Wahl et al. · Molecular and Cellular Biology · 1982 · 410 citations · Full text

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